Chun-Rong Chen Selected Research

Graves Disease (Basedow Disease)

6/2015	Evidence that TSH Receptor A-Subunit Multimers, Not Monomers, Drive Antibody Affinity Maturation in Graves' Disease.
5/2015	A unique mouse strain that develops spontaneous, iodine-accelerated, pathogenic antibodies to the human thyrotrophin receptor.
1/2015	Crystal structure of a TSH receptor monoclonal antibody: insight into Graves' disease pathogenesis.
1/2013	Probing structural variability at the N terminus of the TSH receptor with a murine monoclonal antibody that distinguishes between two receptor conformational forms.
4/2012	Long term persistence of thyrotropin receptor antibodies in wild-type and transgenic mice in a Graves' disease model.
9/2011	Insight into thyroid-stimulating autoantibody interaction with the thyrotropin receptor N-terminus based on mutagenesis and re-evaluation of ambiguity in this region of the receptor crystal structure.
7/2011	An attempt to induce "Graves' disease of the gonads" by immunizing mice with the luteinizing hormone receptor provides insight into breaking tolerance to self-antigens.
1/2011	Exceptional hyperthyroidism and a role for both major histocompatibility class I and class II genes in a murine model of Graves' disease.
3/2009	Evidence that shed thyrotropin receptor A subunits drive affinity maturation of autoantibodies causing Graves' disease.
4/2008	Shared and unique susceptibility genes in a mouse model of Graves' disease determined in BXH and CXB recombinant inbred mice.

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Chun-Rong Chen Research Topics

Disease

22	Graves Disease (Basedow Disease) 06/2015 - 07/2002
21	Hyperthyroidism 05/2015 - 10/2003
5	Thyroiditis 01/2012 - 10/2003
3	Hyperplasia 10/2012 - 11/2009
2	Thyrotoxicosis 05/2015 - 06/2003
1	Thyroid Neoplasms (Thyroid Cancer) 01/2018
1	Neuroendocrine Tumors (Neuroendocrine Tumor) 10/2012
1	Bacterial Infections (Bacterial Infection) 01/2012
1	Nonautoimmune Hyperthyroidism 11/2010
1	Autoimmune Diseases (Autoimmune Disease) 09/2010
1	Glucagonoma 11/2009
1	Islet Cell Adenoma (Islet Cell Tumors) 11/2009
1	Vitamin D Deficiency 02/2009
1	Hypothyroidism 12/2007
1	Infections 06/2006
1	Experimental Autoimmune Myasthenia Gravis (Autoimmune Experimental Myasthenia Gravis) 12/2005
1	Inflammation (Inflammations) 11/2005

Drug/Important Bio-Agent (IBA)

30	Thyrotropin Receptors (Thyrotropin Receptor)IBA 01/2018 - 07/2002
15	AntibodiesIBA 09/2012 - 10/2003
9	Thyroid-Stimulating ImmunoglobulinsIBA 01/2015 - 07/2002
8	AutoantibodiesIBA 06/2015 - 06/2003
5	Proteins (Proteins, Gene)FDA Link 01/2012 - 05/2003
4	AutoantigensIBA 01/2012 - 06/2003
3	DNA (Deoxyribonucleic Acid)IBA 09/2012 - 10/2003
3	EpitopesIBA 01/2012 - 03/2009
3	Thyroglobulin FDA Link 09/2010 - 01/2005
2	Monoclonal AntibodiesIBA 01/2015 - 06/2006
2	Glucagon Receptors (Glucagon Receptor)IBA 10/2012 - 11/2009
2	Long-Acting Thyroid Stimulator (LATS)IBA 04/2012 - 06/2006
2	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 10/2010 - 07/2002
2	Iodide Peroxidase (Deiodinase)IBA 09/2010 - 12/2007
2	Amino Acids FDA Link 08/2010 - 03/2004
2	Peptides (Polypeptides)IBA 12/2005 - 03/2004
1	LigandsIBA 01/2018
1	IodineIBA 05/2015
1	Thyroid HormonesIBA 05/2015
1	Leucine (L-Leucine)FDA Link 01/2013
1	Protein Subunits (Protein Subunit)IBA 01/2012
1	Freund's AdjuvantIBA 01/2012
1	LH Receptors (LH Receptor)IBA 07/2011
1	Glutamic Acid (Glutamate)FDA Link 11/2010
1	Codon (Codons)IBA 11/2010
1	Lysine (L-Lysine)FDA Link 11/2010
1	Glucagon (Glukagon)FDA Link 11/2009
1	difluprednate FDA Link 03/2009
1	Vitamin D FDA LinkGeneric 02/2009
1	CD40 Ligand (CD40L)IBA 05/2006
1	Abatacept (Orencia)FDA Link 05/2006
1	DisulfidesIBA 01/2006
1	cathepsin SIBA 12/2005
1	Peptide Hydrolases (Proteases)FDA Link 11/2005
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 11/2005
1	IodidesIBA 01/2005
1	CytokinesIBA 11/2004
1	Immunoglobulin G (IgG)IBA 11/2004
1	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 03/2004
1	Interferon-gamma (Interferon, gamma)IBA 03/2004
1	HLA-DR3 Antigen (HLA DR3 Antigen)IBA 10/2003
1	AntigensIBA 10/2003

Therapy/Procedure

2	Therapeutics 01/2018 - 11/2010
1	Immunotherapy 05/2015
1	Injections 03/2004